BUPACIN PLUS

For the treatment of theileriosis (east coast fever) particularly for advanced cases with pulmonary oedema.

Buparvaquone kills theilerial schizonts (in lymphoid cells) and piroplasms (in red blood cells) and it suppresses pre-schizont stages during the incubation period of disease. Buparvaquone kills the parasite through its actions on their mitochondrial electron transport (respiratory) system. Furosemide is a diuretic, which resolves pulmonary oedema.

Due to the inhibiting effect of theileriosis on the immune system, vaccination should be delayed until the animal has recovered from theileriosis.

Localised swelling may occur at injection sites but it resolves in a few days. BUPACIN PLUS is very safe so overdosage is unlikely to cause significant adverse effect. BUPACIN PLUS must be administered only by the Intramuscular route. Intravenous injection may cause severe shock. BUPACIN PLUS is poorly mobilized after Subcutaneous injection and its curative effect is greatly reduced. Furosemide is chemically similar to the sulphonamides so BUPACIN PLUS should not be used in animals with sulphonamide sensitivity.

Cattle and Sheep :

Injection by the Intramuscular route into the neck muscles at the rate of 1 ml/20 kg (2.5 mg per kg of Buparvaquone and 2.75 mg per kg of Furosemide). Repeat after 48 hours. In cases of exceptionally severe infections with pulmonary oedema, further treatment at half the dosage rate may be required at 24 hours interval. It should not be given by Intravenous or Subcutaneous Injection. Do not administer more than 10 ml on one side.

Milk for human consumption should not be taken from animals treated with BUPACIN PLUS until atleast 48 hours after treatment. Milk for animals treated with BUPACIN PLUS is safe for consumption by Calves. Animals should not be slaughtered for human consumption until at least 42 days after treatment with BUPACIN PLUS.